The near-perfect alignment of Alzheimer’s and other dementias to the aging mega-trend brings about urgency for innovation. Absent new innovations in effective therapies, diagnostics, caregiving and social framing, Alzheimer’s will continue to be a barrier to healthy aging and fiscal sustainability. However, even with great innovation, if care at the bedside is not transformed, patients will not benefit. Progress in this space will depend on value-based incentives and new paradigms for diagnosis, care and other supports. Programs like the Davos Alzheimer’s Collaborative are using implementation science tos tudy the impact of innovation in real-world settings. Panelists will describe efforts to reframe Alzheimer’s to help remove the stigma, prepare health systems, and spur innovation.